The first Wesleyan Chapel was built in Ashton in 1781, and was used as a preaching house, supplemented by the services at the parish church of St Michael. Members were expected to take communion in an Anglican church four times a year.

The pictured chapel was built in 1851 on Stamford Street, on the same site as an earlier chapel from 1804 when the street was called New Street. It was built across the road from the Methodist New Connection Chapel, which had been built in 1797 and then barred its doors to Wesleyans.

The Wesleyan Chapel was demolished in the early 1960s.